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KMID : 1007520080170010130
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Food Science and Biotechnology
2008 Volume.17 No. 1 p.130 ~ p.134
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Hypoglycemic Effect of Onion Skin Extract in Animal Models of Diabetes Mellitus
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Lee Soo-Kyung
Hwang Ji-Yeon
Kang Ming-Jung
Kim Young-Mee
Jung Suk-Hee
Lee Jai-Hyun
Kim Jung-In
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Abstract
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Hypoglycemic effect of onion skin extract in vitro and in vivo was investigated. A methanol extract of onion skin inhibited yeast α-glucosidase with an IC50 of 0.159 mg/mL. A single oral administration of the onion skin extract (500 mg/kg) significantly lowered the postprandial area under the glucose response curve to starch (1 g/kg, p<0.05). Three-week-old db/db mice were fed an AIN-93G diet or a diet supplemented with a 0.5% onion skin extract for 7 weeks after a 1-week adaptation period. Consumption of onion skin extract significantly reduced the levels of plasma glucose, insulin, and blood glycated hemoglobin as compared with the control group (p<0.05). These findings suggest that onion skin is effective in controlling hyperglycemia in animal models of type 2 diabetes mellitus, at least in part by inhibiting α-glucosidase activity.
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KEYWORD
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onion skin, hypoglycemic effect, α-glucosidase, glucose, db/db mouse
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